We recently demonstrated that respiratory diseases, such as chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF), exhibit lipointoxication signatures characterized by excessive levels of saturated PLs, leading to endoplasmic reticulum stress, interleukin-8 secretion, and bronchoconstriction [4]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.