Significant increases in the thick myelinated axon (G-ratio < 0.8) and decreases in the demyelinated axon (0.8 < G-ratio < 1) were observed in BNIP3 KO mice (Figure 4B), suggesting that BNIP3 KO may maintain axonal myelination after preconditioning and stroke. Here, BNIP3 is linked to stroke disorder.