In addition, Kang et al. [41] also found a similar conclusion in human studies, showing that dietary capsaicin (200–400 ppm) can reduce obesity and promote intestinal health by increasing the Fractions/Bacteroidetes ratio and Faecalibacterium abundance, and at the same time increasing the level of plasma glucagon such as GLP-1 and GIP. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.