As no esophageal stenosis was found by X-ray esophageal fluoroscopy, it is logical to speculate that eosinophil infiltration in the muscle layer of the esophagus may induce the esophageal dismotility and loss of SOX-10-IR cells, which may be related to the release of eosinophil secretion products with muscle and nerve activities, disturbance of peristalsis and LES relaxation, or release of cytotoxic eosinophil secretion products, such as ECP and EDN [8]. This evidence concerns the gene RNASE3 and Esophageal stenosis.