We also found eosinophil infiltration in the muscle layer of the esophagus and its positive correlation with ganglionitis and myenteric plelux damage in AC patients [7], as substances released by eosinophils, such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxins (EDN), can damage nerves [8], and eosinophil infiltration in the esophageal muscle before POEM is associated with a poor prognosis of treatment (Z = 3.50, p = 0.030) [7]. Here, RNASE3 is linked to tenosynovitis.