Canonical pathway analysis indicated that the differential proteins were enriched in granulocyte adhesion and diapedesis, STAT3 pathway, IL-17 signaling, erythropoietin signaling pathway, agranulocyte adhesion and diapedesis, atherosclerosis signaling, HMGB1 signaling, micropinocytosis signaling, clathrin-mediated endocytosis signaling, glucocorticoid receptor signaling, HIF1α signaling, and crosstalk between dendritic cells and natural killer cells (Figure 1D). This evidence concerns the gene HMGB1 and atherosclerosis.