In addition, we performed flow cytometric analyses in four AVM patients: patient 41 (PWS), patient 45 (PWS), patient 49 (AVM of the shoulder), and patient 50 (AV fistula (wrist) and previous AVM of the spine in CLOVES syndrome) observed a decreased expression of CD63 hinting at an impaired delta granule secretion in three out of the four patients. The gene discussed is CD63; the disease is CLOVES syndrome.