This study demonstrated that KRT6A (log2FC −5.47), KRT14 (log2FC −3.71), S100A2 (log2FC −3.23), and KRT17 (log2FC −2.56) have significant diagnostic potential for NSCLC (Table S1), consistent with a previous study using overlapping feature selection methods in which these genes were ranked as having one of the highest diagnostic potentials for classifying LUAD and LUSC [33]. The gene discussed is S100A2; the disease is non-small cell lung carcinoma.