We systematically illustrated the UNC5A mRNA expression profile, prognostic value, mutation patterns, gene enrichment of UNC5A and co-expressed genes, immune infiltration, relationships with various immunomodulators, tumor mutation burden (TMB), neoantigen, immune checkpoint (ICP) genes, tumor microenvironment (TME), and tumor microsatellite instability (MSI). This evidence concerns the gene UNC5A and neoplasm.