UNC5A and hereditary pheochromocytoma-paraganglioma: For DFI, Cox regression showed that a high UNC5A level was a risk factor for LUSC (HR = 1.20, p = 0.01) and testicular germ cell tumors (TGCT, HR = 1.41, p = 0.01) but served as a protective factor for pheochromocytoma and paraganglioma (PCPG, HR = 0.57, p = 2.1 × 10−5), and LGG (HR = 0.70, p = 0.03), as shown in Figure 3A. Kaplan-Meier curves showed that patients with high UNC5A expression had worse DFI than those with low UNC5A levels in adrenocortical carcinoma (ACC) and TGCT (Figure 3B,D).