Palladium pyrithione complex (PdPT), a broad-spectrum DUB (including USP7, USP10, USP14, USP15, USP25, and ubiquitin C-terminal hydrolase L5 (UCHL5) inhibitor, can also cause GPX4 protein ubiquitinated degradation in non-small cell lung cancer cells [93]. The gene discussed is ZUP1; the disease is non-small cell lung carcinoma.