In recent years, pyroptosis has participated in many disease processes, including viral infection [18], tumors [19], and neurodegenerative diseases [20], etc. A broad set of studies have shown that NLRP3 inflammasome-mediated pyroptosis plays a significant role in IDD, and the inhibition of pyroptosis can alleviate IDD progression [21,22,23]. Here, NLRP3 is linked to intervertebral disk degenerative disorder.