This suggests that the expression level of lncRNA NEAT1 is spatiotemporally specific, with decreased expression in the early stage of AD, leading to reduced Aβ clearance; with the accumulation of Aβ, lncRNA NEAT1 expression increases, further promoting the production of Aβ, thus forming a vicious cycle leading to the development of AD. The gene discussed is NEAT1; the disease is Alzheimer disease.