After pretreatment with AAV8-Il18bp, inflammatory cell infiltration, such as lymphocytes, in the confluent area was significantly reduced, there was only partial inflammatory damage to the bile ducts, and the degree of phlebitis was less severe, which indicated a rejection reaction of grade I. Our experiments confirmed that AAV8-Il18bp attenuated immune rejection of liver tissues and maintained normal physiological functions of the liver. This evidence concerns the gene IL18BP and phlebitis.