All the above findings reveal that PRR11 serves as an oncogenic factor in cellular proliferation, migration, invasion, cell-cycle progression, apoptosis and autophagy in human cancers, including TSCC, ESCC, NSCLC, BRCA, GC, CRC, HCC, HCCA, Pancreatic cancer, Ovarian cancer and Osteosarcoma. Here, PRR11 is linked to esophageal squamous cell carcinoma.