All the above findings reveal that PRR11 serves as an oncogenic factor in cellular proliferation, migration, invasion, cell-cycle progression, apoptosis and autophagy in human cancers, including TSCC, ESCC, NSCLC, BRCA, GC, CRC, HCC, HCCA, Pancreatic cancer, Ovarian cancer and Osteosarcoma. The gene discussed is PRR11; the disease is hepatocellular carcinoma.