In vitro, cellular proliferation and cell-cycle progression were evidently boosted by PRR11 in TSCC, ESCC, NSCLC, BRCA, GC, CRC, HCC, HCCA, Pancreatic cancer, Ovarian cancer and Osteosarcoma [4,5,7,8,10,12,13,14,16,19,21]. This evidence concerns the gene PRR11 and osteosarcoma.