Compared with non-tumorous tissues, PRR11 is evidently upregulated in tumor tissues, including ESCC, NSCLC, CRC, HCC, Pancreatic cancer, Ovarian cancer and Osteosarcoma, which would contribute to the improvement of clinical diagnosis in these cancers [2,4,7,9,14,15,19,20,21,34]. Here, PRR11 is linked to esophageal squamous cell carcinoma.