ATP7B and Wilson disease: Whole-exome sequencing provides detailed information on the underlying genotype [37], the ultrafiltrable and exchangeable copper can be determined [38] and used as a new tool in the diagnosis of WD [39], the ATP7B protein can be quantified in dried blood spots [40], the incorporation of radioactive copper into ceruloplasmin can be tested [41] and the retention of radioactive copper in the liver can be analyzed by PET [42].