The average immunoreactivity of GALR1 and GALR3 in muscularis externa plexuses close to the CRC tissue was slightly reduced as compared to the plexuses distant from the tumour, while GALR2 immunoreactivity reminded unchanged (p = 0.0351, p = 0.0204 and p = 0.1109, respectively, Figure 2). This evidence concerns the gene GALR2 and neoplasm.