Remarkable in this context that other OGT inhibitors such as OSMI-1 and benzyl 2-acetamido-2-deoxy-α-D-galactopyranoside as well as OGT knockdown using shRNA were reported to induce characteristic signs of neutrophilic differentiation including the surface expression of CD11b and CD14 markers in HL-60 and OCI-AML3 leukemia cells, albeit with some cytotoxic effects [32]. The gene discussed is ITGAM; the disease is leukemia.