LGALS3 and cancer: As such, many galectins (galectin-1, galectin-3, galectin-4, galectin-7, and galectin-10) are detectable in human plasma by mass spectrometry [20] and claimed to have diagnostic value for cancer and cardiovascular diseases [51,52] while others like galectin-12 may accumulate in cytoplasm by binding with lipid droplets [53].