During zinc deficiency, studies reported an imbalance between Th1 and Th2 cell differentiation, resulting in a diminished Th1 immune response with lowered IFN-γ and IL-2 production, whereas the Th2 cytokines (IL-4, IL-6, and IL-10) remain unaffected [249,259,260]. This evidence concerns the gene IL6 and Zinc deficiency.