CD276 and neoplasm: Figure 6A shows the antitumor effects of B7-H3-targeted CAR-T cells on CP organoids. When the diameter of CP organoids is about 100 μm or beyond, only limited inhibition effects were observed after treatment with CAR-T cells (Figure 6B). In contrast, antiB7-H3-DM1 exhibited obvious tumor-killing effects on CP organoids from six clinical samples (Figure 6C,D).