CD276 and neoplasm: In the present study, we established a CP organoid model for the first time, and using this model, we found that although B7-H3-targeted CAR-T cells show obvious tumor-killing effects in the traditional 2D cell culture model, limited antitumor effects were observed in the 3D organoid model, while the B7-H3-targeted antibody-DM1 conjugate exhibited a potent tumor suppression function in both the 2D and 3D models.