This is not only limited to BC, as the proliferation marker Ki-67 is also localized throughout the organotypic epithelium in Cosmc hypermethylated pancreatic cancer cells, whereas unmutated pancreatic cancer cells showed Ki-67 only in basal cells, suggesting that loss of function due to Cosmc hypermethylation could induce pancreatic cancer cell proliferation [98]. This evidence concerns the gene MKI67 and familial pancreatic carcinoma.