It was also found that EMT directly or indirectly downregulated the expression of E-cadherin to regulate the development of CRC, mainly through three core transcription factors: (1) the transcription factors of the Snail zinc finger protein family (Snail1 and Slug); (2) the E-box binding zinc finger protein homology protein family (ZEB1 and ZEB2) [29]; and (3) the basic helix-ring-helix family of transcription factors (Twist1, Twist2, and E12). This evidence concerns the gene ZEB1 and colorectal carcinoma.