Considering CFL2 a candidate gene for nemaline myopathy, some studies have shown that the mutation from G to A in the coding region position 103 of the CFL2 gene can induce the occurrence of human nemaline myopathy, and the CFL2 gene can regulate the expression of key factors CAM and MEF2C in myofibroblast signal pathway, resulting in a change in muscle properties [12]. Here, MEF2C is linked to nemaline myopathy.