Deficiency in WASp connects perturbations in actin assembly with T cell, B cell, and myeloid cell abnormalities,[33] as well as associated complications including infection, autoimmunity, inflammation, and malignancy.[11] Subsequently, keywords such as “mutation,” “thrombocytopenia,” “immunodeficiency,” “immune dysregulation,” “stem cell,” and “hematopoietic cell transplantation” appeared frequently in the last 5 years, indicating that the mechanistic underpinnings of immune dysfunction and treatment modalities will remain research hotspots over the next few years. The gene discussed is WAS; the disease is Autoimmunity.