At normal levels, it can inhibit Th1 and Th2 responses and stimulate Treg T cells to secrete interleukin 10 (IL10) and transforming growth factor beta (TGF-β).[6] It can also act on helper T lymphocytes 17 (Th17) lymphocytes by inhibiting the secretion of interleukin17, which has been associated with the presence of severe asthma.[7]. The gene discussed is IL10; the disease is asthma.