In previous reports, DILE generally showed only some non-serious symptoms (e.g., rash, arthritis, and serositis) and tended to resolve, requiring weeks to months after drug withdrawal.[31] The main positive antibodies in DILE are ANA and anti-histone antibodies; anti-dsDNA is present only in rare cases and depends on the type of causative drug, for example TNF [tumor necrosis factor (TNF) -α inhibitors.[32] Interestingly, our patient presented with severe organ involvement (e.g., LN and pancytopenia), which did not disappear after IFN-α2b discontinuation. The gene discussed is TNF; the disease is lobular neoplasia.