In terms of prognosis, some studies have showed that most TFEB-associated renal cell carcinoma exhibit inert behavior, and approximately 17% of the cases exhibit invasive behavior.[13] Wyvekens et al[10,28] also pointed out that TFEB-associated renal cell carcinoma seems to have a better prognosis. Here, TFEB is linked to hereditary clear cell renal cell carcinoma.