TFEB-associated renal cell carcinoma is very rare[10], By 2017, only about 50 cases of TFEB-associated renal cell carcinoma were reported.[11] The main partner gene fused with TFEB is MALAT1 (also known as α gene).[12] Other fusion partner genes have recently been described as ACTB, NEAT1[13] and melanin TFEB-associated renal cell carcinoma.[14] Fusion of TFEB translocation with other genes is a common feature of these tumors, and an increasing number of partner genes have been identified. Here, ACTB is linked to renal cell carcinoma.