MITF translocation renal cell carcinoma was classified as a separate subtype by the WHO in 2016.[1] MITF translocation renal cell carcinoma has been identified as an independent entity in renal cell carcinoma and consists of 4 transcription factors: MITF, TFEC, TFEB and TFE3. The gene discussed is TFEC; the disease is hereditary clear cell renal cell carcinoma.