But unfortunately has low sensitivity, as not all TFEB-associated renal cell carcinomas express PAX8.In which case FISH may be an effective method for this distinction.[23] In summary, for TFEB-associated renal cell carcinoma, in the diagnosis and differential diagnosis of translocation renal cell carcinoma and other types of renal cell carcinoma, even between MIT family translocation renal cell carcinoma, morphology, and IHC are good identification methods, and FISH is sometimes necessary. The gene discussed is TFEB; the disease is hereditary clear cell renal cell carcinoma.