TFE3 and hereditary clear cell renal cell carcinoma: In 2016, a new subtype, known as microphthalmia-associated transcription (MIT) family translocation renal cell carcinoma, was added to the WHO classification of renal cell carcinoma.[1] Renal cell carcinoma, which is composed of 4 transcription factors, microphthalmia — associated transcription factor (MITF), TFEC, TFEB, and TFE3, has been identified as an independent entity known as MITF translocation carcinoma.