In 2016, a new subtype, known as microphthalmia-associated transcription (MIT) family translocation renal cell carcinoma, was added to the WHO classification of renal cell carcinoma.[1] Renal cell carcinoma, which is composed of 4 transcription factors, microphthalmia — associated transcription factor (MITF), TFEC, TFEB, and TFE3, has been identified as an independent entity known as MITF translocation carcinoma. Here, MITF is linked to hereditary clear cell renal cell carcinoma.