TNF and Familial prostate cancer: A recent study reported that TBKBP1 and TBK1 generate a growth factor signaling axis, mediating immunosuppression and tumorigenesis.[27] As one of the members of the TNF family, TNFSF10 can induce cell apoptosis in multiple cancer types, including prostate cancer.[28,29] These findings indicated that 6 screened prognosis-related genes could impact tumorigenesis and progression functionally, helping us better understand their values in survival prediction and immunotherapeutic response assessment.