CASP8 and Familial prostate cancer: As a caspase protein, CASP8 is essential in apoptosis, necroptosis, and pyroptosis.[16] Improved mRNA levels of CASP8 were identified in the patients with recurrent prostate cancer compared with those with non-recurrent prostate cancer.[17] Prognostically, enhanced expression levels of CASP8 were correlated with dismal disease-free survival and OS in renal cancer.[17] GRKs are a versatile family of protein kinases.