A recent publication demonstrated that 5 cGAS-STING pathway-related genes (IFNB1, IFNA4, IL6, NFKB2, and TRIM25) could be a good risk factor for predicting OS in patients with gastric cancer.[8] However, to the best of our knowledge, the potential values of cGAS-STING pathway-related genes in the PRAD are still unclear, and this is the first study to detect the potential function of cGAS-STING pathway-related genes in PRAD. Here, TRIM25 is linked to prostate adenocarcinoma.