More importantly, as expected, the expression of SMAD7 was knocked down in METTL3‐depleted CRC cells using a SMAD7‐specific siRNA (Fig. 7I, Fig. S14I), which markedly promoted the suppression of migration and invasion resulting from depletion of METTL3 (Fig. 7J,K, Fig. S14J,K). The gene discussed is METTL3; the disease is colorectal carcinoma.