In an attempt to elucidate the biological function of m1A modification in CRC, we first detected the correlation between the OS in CRC patients and the expression of m1A regulators using the online bioinformatics tool GenomicScape, including methyltransferases TRMT6, TRMT61A, TRMT61B and demethylases ALKBH1 and ALKBH3. This evidence concerns the gene TRMT61A and colorectal carcinoma.