More importantly, as expected, the expression of SMAD7 was knocked down in METTL3‐depleted CRC cells using a SMAD7‐specific siRNA (Fig. 7I, Fig. S14I), which markedly promoted the suppression of migration and invasion resulting from depletion of METTL3 (Fig. 7J,K, Fig. S14J,K). This evidence concerns the gene SMAD7 and colorectal carcinoma.