PDK4 and asthma: As illustrated in Fig. 9, PDK4 (P-value < 0.001) and ZBTB16 (P-value < 0.01) were up-regulated in asthma group, while WNT5A (P-value < 0.05), NR4A3 (P-value < 0.001) and WIF1 (P-value < 0.05) were down-regulated.