Yang et al. [41] showed that IL-10 derived from M2 macrophage promotes the stemness in non-small cell lung cancer cells via JAK1/STAT1/NF-κB/Notch1 signaling, and further, they confirmed that blockage of this pathway could inhibit tumor growth in an in vivo model. The gene discussed is NOTCH1; the disease is non-small cell lung carcinoma.