Furthermore, N-Myc downstream-regulated 1(NDRG1) and DNA protein cross-link (DpC) reduced cross-talk between pancreatic cancer cells and pancreatic stellate cells by inhibiting β-catenin and YAP/TAZ nuclear localization and promoting DKK1, a Wnt inhibitor, in pancreatic cancer cells [185]. Here, NDRG1 is linked to familial pancreatic carcinoma.