Interestingly, the middle 3 amino acids of the private CDR3 motifs contain significantly higher portion of hydrophobic residues than those of the public motifs, and hydrophobicity has been described as a hallmark of immunogenic neo-epitopes, suggesting that private CDR3 sequences might have higher potential for tumor-Ag recognition [69, 70]. The gene discussed is RENBP; the disease is neoplasm.