In NSCLC, mutational burden and tumor heterogeneity result in highly diverse intratumoral TCR repertoire between samples of different patients, however, T-cell clone overlap analyses between normal lung tissues and NSCLCs showed a good degree of similarity [64] suggesting that several infiltrating clonotypes likely reflect a persistent exposure to pathogens more than a response to specific tumor-Ag. This evidence concerns the gene RENBP and neoplasm.