Shen-Qi series formulas have efficacy for alleviating insulin resistance, promoting b-cell function, and improving intestinal microbiota in the treatment of patients with type 2 diabetes mellitus (T2DM) [22, 23].In addition, it can reduce blood interleukin-6 (IL-6), hs-C-reactive protein and carotid intima-media thickness (CIMT), alleviate clinical symptoms, and improve quality of life in diabetic patients with macroangiopathy [24, 25]. Here, IL6 is linked to Insulin resistance.