More importantly, circ_0083964 deficiency led to a reduction in YY1 level both at protein levels, which was counteracted by the addition of anti-miR-204-5p in RA-FLSs (Fig. 6J), indicating the feedback loop of circ_0083964/miR-204-5p/YY1 in RA. The gene discussed is YY1; the disease is rheumatoid arthritis.