Likewise, the absence of Trem2 has been associated with a decrease in microgliosis in a variety of disease models, but the ultimate effect on the different pathologies and neuronal integrity differs, suggesting that Trem2 mediates microglial responses to amyloidosis even though it does not necessarily affect the total plaque load or protein aggregation [110, 111]. The gene discussed is TREM2; the disease is amyloidosis.