SMIM3 and acute myeloid leukemia: Moreover, in 69 AML with normal karyotype (NK-AML), patients with high SMIM3 expression had a worse 2-year OS than those with low SMIM3 expression (41.1% [26.3–64.0%] vs. 32.8% [18.8–57.0%]; P = 0.046; Fig. 2B).