RRM1 and smallpox: For example, HHV-6A, 6B, and 7 (that were asserted to be increased in AD) have pronounced matches with human telomeric DNA repeats, HHV-3 and HHV-8 contain sequences similar to human thymidylate synthase (TYMS), the HHV-4 genome has matches to human interleukin 10 receptor variant (IL10RV), and the genome of variola virus (the agent of smallpox, also detected in human brain by Readhead et al. contains homologies to human ribonucleotide reductase subunits (RRM1 and RRM2B) (Table S5).