CD40LG and Epstein-Barr virus infection: Sera from patients with Epstein Barr Virus (EBV), a disease that, like P. falciparum, can induce characteristic polyreactive B cell responses, was found to have significantly less reactivity than sera from subjects with acute malaria infection (t-test p values < 0.0001 for both IgG and IgM when compared to two separate time points after EBV infection, generally 6 weeks and 6 months after infection), indicating that cross-reactivity is not necessarily correlated with broad, disease-independent poly reactive B cell responses (Fig. 1A).