CD40LG and infection: In S1-reactive antibody responses in 131 longitudinal samples from 21 Senegalese subjects, IgG and IgM responses peaked 0–4 weeks post P. falciparum infection for all subjects, decreased with time, and, in some subjects, were boosted by subsequent reinfections (boosting in 1 of 4 IgG samples and 2 of 4 IgM samples with confirmed P. falciparum subsequent re-infection) (Fig. 1C).