Anxiety-like phenotypes and abnormal fear learning are observed in mice where CaV1.2 is deleted in glia as well as neurons11,12,14,59 and in some neuron-specific conditional cKO mouse models12,14,41,53, but not in Syn1-Cre neuron-specific conditional knockouts28,29 including the work reported here. This evidence concerns the gene CACNA1C and Anxiety.