Our findings provide a novel link between impaired SRF signaling and the perturbation of cellular functions that lead to cardiac defects in cardiomyopathy caused by mutations in LMNA. Given that SRF transcriptional activity is dependent on actin cytoskeleton dynamics24, it is becoming increasingly clear that the two cytoskeletal systems work together in core cellular processes and that their functional dynamics are often intimately interwoven11. Here, LMNA is linked to cardiomyopathy.