LMNA and cardiomyopathy: The development of cardiomyopathy caused by mutations in LMNA was previously correlated with the remodeling of the gap junction protein Cx43 and characterized by a loss of localization at intercalated discs and redistribution to the lateral sides of cardiomyocyte membranes (i.e., “lateralization”) in the hearts of Lmnap.H222P/H222P mice9,61.