SPI1 and Alzheimer disease: Kaplan‒Meier analyses investigating the effect of the interaction of CRP concentration with these three SNPs highlighted significantly lower AD-free probability among subjects having CRP greater than 11 mg/L and at least one of the following genotypes: SPI1 rs1057233-AA (p = 0.001), CD33 rs3865444-CC (p = 0.006) or CLU rs9331896-CC/CT (p = 0.009) (Fig. 2).