CLU and Alzheimer disease: In this study, we selected ten common single nucleotide polymorphisms (SNPs) in reported AD risk loci encoding proteins related to inflammation/immune function, including clusterin (CLU, rs9331896) [13], Spi-1 proto-oncogene (SPI1, rs1057233) [14] and CD33 molecule (CD33, rs3865444) [15–17].