In addition, five of the hypomethylated CpGs in DKD cases overlapped with predicted transcription factor binding sites for the following factors (Supplementary Table 4): the homeodomain leucine zipper-containing factor (cg22815707 in ANKRD12), the peroxisome proliferator-activated receptor gamma (cg17058475 in CPT1A), the sterol regulatory element-binding protein 1 (cg19996939), the transcription factor AP-2 alpha (cg05710777 within LINC10800) and the p53 and transcriptional activator Myb (both overlapped with cg01895164). The gene discussed is TP53; the disease is diabetic kidney disease.