Conditional knockout of SCAP in macrophage renders the mice resistant to intranasal infection of murine gamma herpesvirus 68 (MHV68),158 while in shRNA-mediated SCAP knockdown mice, the innate immune response against intravenous infection with HSV-1 was severely impaired.171 The discrepancy may arise from the different knockout strategies and types of infection, as systemic knockout of SCAP may elicit a profound effect beyond STING. Here, SCAP is linked to infection.