STING1 and neoplasm: The demethylating agent 5-aza-2’-deoxycytidine (5AZADC) can recapitulate STING expression,138 which would also promote MHC-I-mediated tumor antigen presentation and T cell recognition in tumor cells.139 IFN-α has been reported to increase STING expression through a STAT1 binding site on the STING promoter.140,141 In type 2 immune environment, STING expression in epithelial cells of nasal tissue was negatively regulated by IL-4 and IL-13 in a STAT6-dependent manner.142