ALX4 and cancer: In this condition, STING activates nuclear factor κB (NF-κB) to trigger aristaless-like homeobox 4 (ALX4) transcription, which is a key effector in brain development.208 Interestingly, type I interferon signaling of STING has also been reported to control nociception in sensory neurons.209 Thus, the STING agonist may also alleviate chronic pain, including cancer pain.