In this condition, STING activates nuclear factor κB (NF-κB) to trigger aristaless-like homeobox 4 (ALX4) transcription, which is a key effector in brain development.208 Interestingly, type I interferon signaling of STING has also been reported to control nociception in sensory neurons.209 Thus, the STING agonist may also alleviate chronic pain, including cancer pain. This evidence concerns the gene STING1 and cancer.