CGAS and neoplasm: Interestingly, the tumor cell itself can intrinsically activate the cGAS–STING pathway due to its genome instability.186 The rupture of the micronuclear envelope exposes the genome DNA to the cytosol and in some cases mitochondrial dysfunction results in the release of mitochondrial dsDNA.187 Such tumor cell-derived cGAMP can be transferred into immune cells through cell gaps.