Another study designed a thiolated and Mn2+ coordinated cGAMP nanovaccine, which achieve improved control of both the primary and distal tumors.242 Lastly, for KRAS-LKB1 mutant lung cancers with STING silenced in epigenetics, it is reported that a single treatment of MPS1 inhibitor can potently re-engage STING activation and restores T cell infiltration through epigenetic de-repression of STING.243 Substantial future work is needed to carry forward such a combination into advanced clinical trials. This evidence concerns the gene KRAS and lung cancer.