7B2 precursor (Jarvela et al., 2018), cathepsin B (Hook et al., 2020), and heat shock protein 70 (Turturici et al., 2011) were detected as ApKHC1 cargo is involved in Parkinson’s disease, Alzheimer’s disease, polyglutamine diseases, and amyotrophic lateral sclerosis. Here, CTSB is linked to early-onset autosomal dominant Alzheimer disease.