Concomitant decreases in AMPARs, neurogenesis, BDNF-TRKB pathway, and mTORC1 signaling have been reported in both depressed patients (Jernigan et al., 2011; Kang et al., 2012) and animal models mimicking aspects of depressive disorders (Duman, 2018; N. Li et al., 2010, 2011; Zhou et al., 2014). The gene discussed is BDNF; the disease is depressive disorder.