In the respiratory system, overactivation of TRPV4 affects excitability of bronchopulmonary sensory neurons (Gu et al, 2016) and TRPV4-deficient mice are protected from airway remodeling that occurs in both large and small airways relevant to miscellaneous respiratory diseases including asthma, a chronic inflammatory disease of the upper airways (Gombedza et al, 2017). The gene discussed is TRPV4; the disease is asthma.