Given that AEG-1 is a key regulator of NASH and HCC and that AEG-1 S-palmitoylation negatively regulates AEG-1 function andkeeps its inflammatory and oncogenic functions in check, it wouldbe worthwhile to identify the depalmitoylases that can remove thepalmitoylation of AEG-1. Here, MTDH is linked to hepatocellular carcinoma.