For example, ZDHHC6 is reported to palmitoylate MYD88and promote Toll-like receptor signaling.36 ZDHHC6 also palmitoylates CD36, which is reported to promote lipiduptake in macrophages and the formation of foam cells.37 The promotion of lipid uptake by ZDHHC6 viaCD36 is particularly interesting and may also be connected to liverdiseases, such as NASH. Here, ZDHHC6 is linked to metabolic dysfunction-associated steatohepatitis.