VEGFD and endometriosis: Other studies have found that antisense hypoxia-inducible factor (aHIF) is highly expressed in the exosomes derived from patients serum with endometriosis, and the aHIF shuttled by exosomes is transferred from endometriotic stromal cell (ECSC) to HUVECs, which in turn activate vascular endothelial growth factor (VEGF-A), VEGF-D, and basic fibroblast growth factor inducing angiogenic behavior in HUVECs, thereby promoting endometriosis angiogenesis [47,48].