They are conversely linked to tolerance to hypoxia [5,14], and are quantified herein alongside TAR DNA-binding protein 43 (TDP-43)—another protein aggregating in diseases such as amyotrophic lateral sclerosis, Parkinson’s disease, and frontotemporal dementia [15]—and the extracellular matrix protein fibronectin. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.