Among the DEGs that were highly expressed in B6J mice compared to B6N mice, three genes: insulin degrading enzyme (Ide), adenylosuccinate synthase 2 (Adss2), and ectonucleotide triphosphate diphosphohydrolase 4 (Entpd4) in the ND group and five genes: Ide, Adss2, Entpd4, B-TFIID TATA-box binding protein associated factor 1 (Btaf1), and transmembrane protein 267 (TMEM267) in the HF group overlapped in all seven tissues examined in the present study. The gene discussed is IDE; the disease is hydrops fetalis.