Two of the twelve independent MHC variants identified for association with MS in the Hispanic sample (Table 1) demonstrated global ancestry risk modification (p < 0.05) (Table 3); rs2844503 (additive OR = 1.34 in the full sample), an intergenic variant flanking MICB-DT, and rs3021302 (recessive OR = 3.18 in the full sample), an intergenic variant flanking HLA-DQB1. The gene discussed is MICB; the disease is myeloid sarcoma.