While there has been some previous evidence for association of variation within HLA-F-AS1 and MS [36], moderate LD exists between HLA-A:02:01 and rs760145 in Europeans (R2 = 0.2) while LD is negligible in African Americans and may explain why HLA-F-AS1 has not been indicated as an independent MS locus in more recent studies [1]. The gene discussed is HLA-F; the disease is myeloid sarcoma.