In the marginal analysis of classical alleles (Figs 1 and 2), HLA-DQB1*06:02 indicated the strongest additive association with MS risk in Hispanics (additive OR = 2.52, p = 1.05 x 10−23) (S2 Table); while HLA-DRB1*15:01 indicated the strongest additive association with MS risk in African Americans (additive OR = 1.81, p = 8.00 x 10−05) (S3 Table). Here, HLA-DRB1 is linked to myeloid sarcoma.