FOXA2 and idiopathic pulmonary fibrosis: Presently, the polymorphism is thought to a) disrupt a 25 CpG motif differentially methylated region which is, counterintuitively, hypermethylated in IPF, and b) enhance the binding of the transcription factor Forkhead Box Protein A2 (FOXA2), 32 bp downstream of the SNP, as evidenced by chromatin immunoprecipitation [18].